Objective To find out the effective materials and methods for the prevention of peridural adhension after
laminectomy. Methods
The gel and salviamiltriorrhiza (SMB)-gel were acquired from the Carbomer and SMB.
Laminectomy was performed in L3, L6 on 36 rabbits which had been divided into 4 groups randomly, and resulted in the status of 10 mm×5 mm lamina defect. Different treatments were applied on the 4 groups:group A (blank control), group B (get treated), group C (2% sodium hyaluronate treated), and group D (SMB-gel treated). One specimen of each group was examined under electron transmission microscopy at the 4th
postoperative week. Computed imaging analysis of epidural adhension of each group was also done at the 4th, 6th, and 8th postoperative week. Results At each time, there was statistical difference in the thickness of the adhension between group A, B, C and group D with F values being 128.657,152.246,80.891 respectively. The proliferating fibroblasts could be observed by microscopy at 4th postoperative week in groups A, B and C, while in group D, the proliferation was inactive. Conclusion SMB-gel has been proved to have the best effect in preventing peridural adhesion after laminectomy. SMB can inhibit the fibroblasts from proliferation.