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Shvoong Home>Medicine & Health>The Nephrotoxicity of Long Dan Xie Gan Decoction and the Relevance with Aristolochia manshriensis Ko Review

The Nephrotoxicity of Long Dan Xie Gan Decoction and the Relevance with Aristolochia manshriensis Ko

Article Review   by:TsingHua     Original Author: Chinese Journal of Experimental Traditional Medical Formulae
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Objective:To observe the renal injury in rats induced by Long Dan Xie Gan decoction(LDXGD) and the compatibilition with Aristolochia manshriensis Kom in LDXGD.Method:Separate SD rats to four groups at random,and feed respectively LDXGD containing Aristolochia manshriensis Kom(17.5g·kg~(-1),containing Aristolochia manshriensis Kom 6g·kg~(-1)),LDXGD removed Aristolochia manshriensis Kom(11.5g·kg~(-1)),Aristolochia manshriensis Kom(6g·kg~(-1)) and distilled water for 12 weeks.determine renal functional parameters on 4w,8w,12w.Result:Both Aristolochia manshriensis Kom(6g·kg~(-1)) and the LDXGD containing same dose Aristolochia manshriensis Kom induced significantly renal injury in rats during 12 weeks,and the former caused more seriously damage;the LDXGD removed Aristolochia manshriensis Kom didn't induce damage obviously in rats during 12 weeks.Conclusion:Aristolochia manshriensis Kom in experimental dosage can induce renal injury,and the real toxicity of LDXGD is correlated with the dose of Aristolochia manshriensis Kom in itself;the compatibilition in the complex prescription(LDXGD) relieve possibly the renal toxicity of Aristolochia manshriensis Kom.
Published: January 01, 2006   
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