Objective: To establish the rat model with immunity liver fibrosis and study the effect of composite herbal medicines of Ganxianyu (GXY) on the levels of serum ALT、AST、TP、Alb, and the effect of histopathology in liver. Method: The rat models with immunity liver fibrosis were induced by the human serum Albumin, GXY were taken by gastric infusion respectively as small and large dosage group (6.1 g/kg and 12.2 g/kg) in consecutive 8 weeks. Biejia Ruangan Tablet or colchicines were taken as positive contrast drug. The levels of serum ALT、AST、TP、Alb were detected. The effect of histopathology in liver was observed by optical microscope and electron microscope. Result: GXY could depress the serum levels of ALT、AST, and increase the serum levels of Alb in rat models with immunity liver fibrosis induced by the human serum Albumin in large dosage groups. At the same time, it improved the survival state of experimental rats. Conclusion: GXY could treat liver fibrosis in rat models with immunity liver fibrosis induced by the human serum Albumin.