Aim To investigate the anti-
atherosclerosis mechanisms of the novel compound
pivanampeta in the rabbit model of atherosclerosis.Methods Eighteen male rabbits were randomly assigned to the control,the model and the pivanampeta-treated groups respectively.The rabbits in the model and the pivanampeta-treated groups were fed with hypercholesterol diet.The
carotid in the rabbits was cut into pieces before being stained by HE.The rabbit serum level of TC,LDL-CHO,HDL-CHO,
PGI_2 and TXA_2 was measured.The expression of MCP-1 and IL-8 mRNA on rabbit carotid was determined by semi-quantitative RT-PCR.The vascular relaxation induced by acetylcholine on rabbit carotid was also observed.Results Pivanampeta can
inhibit the formation of atheroslcerotic plaque,improve vascular endothelial function,decrease the plasma level of TXA_2,increase the ratio of PGI_2 to TXA_2 and inhibit the over expression of MCP-1 and IL-8 mRNA in the rabbit carotid.Conclusion The mechanisms underlying the anti-atherosclerotic effects of pivanampeta might be ralated to its ability to improve the endothelial function,decrease the plasma TXA_2 level,as well as inhibit over expression of IL-8 and MCP-1.