Objective To observe the effect of zhibie capsules (ZBC,a TCM preparation) on anti-hepatofibrosis.Methods The model of hepatic
fibrosis (HF) in rats was induced by complex factors of carbon tetrachloride (CCl_4),forage of high fat and alcohol.The effect of ZBC on general condition,the ratios of liver weight to body weight,spleen weight to body weight,liver function,
hydroxyproline (Hyp) content of liver tissue and the pathological tissue changes were observed,and compared with colchicine.Results ZBC could obviously improve the rats′ mental state,appetite and hair luster,increase their body weight,repress the enlargement of liver and spleen,decrease the serum activity of ALT,AST,raise the serum Alb,A/G,decrease the amount of Hyp of the liver,relieve the inflammatory injury,fatty degeneration of the liver cells,and reduce the collagen fibre of the liver.Conclusion ZBC is good at protecting liver cells,improving liver function, reversing hepatic tissue′s pathological change and reversing HF.