Objective This study is to observe the effects of RGD-
peptide (225) (RGD) with 17β-Estrodiol (E 2) on
bone mass,bone mechanical
strength and bone metabolism in ovariectomized (OVX) mice.Methods Bone mineral density (BMD),Bone mineral contend (BMC),bone strength and biochemical markers were measured in each group.45(10-week-old) female CD-1 mice,with an average weight of 29 g,were randomly divided into 5 groups.17β-Estradiol (15μg·kg -1·d -1,injection),RGD-peptide (225) (35 nmol/mouse·d) injection for 7 weeks in ovariectomized mice.And it was compared with sham group and BL group.Results Biomechanical parameters
decreased,BMD and BMC decreased
obviously,and bone turnover also accelerated in OVX mice,compared with sham operated group.After 7 weeks' treatment,the BMD and BMC of RGD Pdypeptide (225) were obviously increased.A part of biomechanical parameters increased and serum ALP significantly decreased in RGD and E 2 group.Conclusion RGD-peptide (225) may increase BMD,BMC,and improve the bone mechanical strength and inhibit the bone turnover obviously.