Objective To investigate the mechanism by which celecoxib inhibits the development of experimental abdominal aortic aneurysms
(AAA). Methods 24 wistar mice were divided into two groups randomly. 12 mice were
experiment group, 12 mice were control group. Celecoxib (25mg/d·kg) was perfused into the experiment group through stomach pipe, and saline was perfused into the control group. The
formation rate of AAA and the histological changes of the aorta of two groups were examined and the expression of MMP - 2 and MMP - 9 were detected by the immunohistochemical analysis and in situ molecular hybridization technique. Results After two weeks' perfusing, the formation rate of AAA of the experiment group was 8. 33% , compared with that of the control group, which was 100% , the difference of the two groups was significance (P<0. 01). The expressions of MMP - 2 and MMP - 9 in experiment group were lower than in control group. Conclusions Celecoxib can prevent the degradation of elastin in vascular wall and inhibit the formation of AAA in mice AAA model through decreasing the expression of MMP - 2 and MMP - 9 in AAA tissue, which provides a feasible theory for treating human small AAA.