Objective To observe the hypoglycemic effect of
epimedium hypoglycemic spring(EHS) and its mechanism involved.Methods After
successive oral administration of EHS,FBG of normal mice,adrenaline-induced
hyperglycemic mice and alloxan-induced hyperglycemic rats were determined.In addition,in alloxan-induced hyperglycemic rats after successive oral administration,the contents of liver's glycogen and histology of pancreas's islet were sludied.Results EHS exhibits no apparent effect on FBG in the normal mice.Meanwhile EHS can effectively decrease FBG in the adrenaline-induced hyperglycemic mice and alloxan-induced hyperglycemic rats.Moreover the contents of the liver's gloycogen in the alloxan-induced hyperglycemic rats can manifest enhanced by ig EHS 100 and 50 mg·kg -1.It is testified histopathogically that pancreas's islet β cell of the alloxan-induced hyperglycemic rats can be protected by ig EHS 100 mg·kg -1.Conclusion EHS can decrease the FBG in adrenaline-induced hyperglycemic mice and alloxan-induced hyperglycemic rats,and its involved mechanism is related to significantly increasing the contents of the liver's gloycogen and protecting pancreas's islet β cell.