AIM:To study the pharmacokinetics and bioequivalence of
glucosamine indometacin enteric-coated tablets (po) in male volunteers.
METHODS: The indometacin concentrations in plasma were determined by HPLC-UV. The test and reference formulations of
glucosamine indometacin enteric-coated tablets were given to 20 healthy male volunteers by randomized crossover, respectively. RESULTS: After a single oral dose of 300 mg glucosmine indometacin enteric-coated test or reference tablets was taken the main pharmacokinetic parameters of indometacin AUC 0-24, AUC 0-∞, t max, c max and t 1/2 were (18±s 4) and (16±3) mg· L·h -1,(19±4) and (18±4) mg·L·h -1,(3.5±0.9) and (3.3±0.9) h, (5.9±2.0) and (6.1±1.6) mg·L -1,(7.6± 2.0) and (7.5±2.9)h respectively. The relative bioavailability F 0-24,F 0-∞ were (109±14) % and (111±17) %. CONCLUSION: No significant difference exists among the pharmacokinetic parameters for the experimental tablets and the reference. The two formulations were bioequivalent.