OBJECTIVE To study the effects of
soybean isoflavones on serum biochemical indexes of
ovariectomized rats.METHOD SD female
rats, 4 months old, were randomly divided into 6 groups according to the body weight and breeding with different dose of soy isoflavones or/and calcium for 2 months. Weighed the rats and killed. Serum biochemical indexes were measured. The womb, right femur and right tibia were weighted.RESULTS
Soybean isoflavones inhibited the addition of rats body mass, and promoted the growth of wombs, and didn't significantly affect serum calcium, serum phosphorus and osteocalcin. Soybean isoflavones could lower the activity of serum alkaline phosphatase, and lightly improve the level of estrodiol and calcitonin. But, the difference between most of these test groups and ovariectomized model group were not significant.CONCLUSION It is concluded that soybean isoflavones can affect the biochemical indexes of ovariectomized female rats, due to their weak estrogenic activity. When combined with calcium, soybean isoflavones could be more effective on the biochemical indexes of
ovariectomized rats.