Objective To explore the change of the activity of matrix metalloproteinase (MMP) of lung tissue in the acute
exacerbation
of COPD rat models and the treatment effect of Tongse granule .Method The acute
exacerbation of COPD animal model was developed by drip Klebs-loeffler bacillus from nasal cavity and the MMP of rat lung tissue was detected by zymography method. Results The 92 , 72, 82, 62 kD levels of lung in acute exacerbation of COPD animal model group, stable model group of COPD, high dosage group, low dosage group,
Chinese herbal medicine control group, western medicine control group were all higher than those of normal controls. The levels of ~92, 72, 82, 62 kD in acute exacerbation of COPD animal model group and western medicine control group were obviously higher than those of stable model group of COPD .Levels of 92, 72, 82, 62 kD of lung in high dosage group and low dosage group were all obviously lower than those of acute exacerbation of COPD animal model group, Chinese herbal medicine control group and western medicine control group. Conclusions Increase of the MMP-2 and MMP-9 activity was related to lung tissue injury. Tongse Granule could treat COPD by inhibiting the activities of MMP-2 and MMP-9.