Aim:To observe the effect of Valeriana Officinalis Var Latifolia Miq(VOL)on
study and
memory ability and
pathomorphology change of
hippocampal region in
vascular dementia model mice. Methods:
Vascular Dementia model in mice was established by clamping of the both common carotid artery repeatedly. Forty Kunming healthy mice were divided into 4 groups randomly,sham-operation group,model group and VOL group.On the 7th, 15th,30th after operation,grade of dementia was evaluated by Step-down avoidance test, pathomorphology change of hippocampal neuron was observed by electron microscope and hematoxylin-eosin( HE), Nissl staining. Results: Laten period in VOL group was shorter than that in model mice( P < 0.01). The quantities of neuron in VOL group in hippocampus CA1 were more than that in model group ( P < 0.01) .The loss of neuron,karyopyknosis in partial neurons and proliferation of glial cells in hippocampal CA1 were found in vascular dementia mice which relived markedly in VOL group. Conclusion: VOL can obviously improve pathomorphology change of hippocampal CA1 neuron and the ameliorate study and memory ability in vascular dementia mice.
More abstracts about the Effect of Valeriana Officinalis Var Latifolia Miq on Study and Memory Ability and Pathomorphology Ch