Objective To study the effect and action mechanism of Naolisu (NLS) Capsule on treating the intelligent disorder of vascular
dementia rats. Method According to Olsson's method, we replicated VaD rats model by blocking bilateral common carotid artery permanently and randomly classified them into six groups, namely, model group, control group, NLS capsule high dosage group, NLS capsule middle dosage group, NLS capsule low dosage group and pseudo-operation group (ten each group). The treatment lasted for twenty-one days. We observed the activity of NOS, nNOS and AchE positive cells in virtue of zymohistochemical, immunohistochemical. Result NOS activity and nNOS positive neuron activity decreased AchE activity increased of hippocampal CA1 area of high dosage NLS capsule and Dihydergotoxine. Conclusion NLS capsule can improve the
cerebral ischemic state, protect cerebral ischemic injury, inhibit the activity of nNOS, can regulate the balance between excitability and inhibitility of central nerves system, increase the tolerance of neurocyte for hypoxia, decline the lose of neuron and improve learning and memory abilities.