Objective: To evaluate the effects of
rebamipide on
gastric mucosal blood flow (GMBF) and gastric bicarbonate secretion and
its protective effect on gastric mucosal lesion by exposure to 0.15 mol/L HCl 40% ethanol in fasted rats. Methods: The study consisted of three parts with five groups each, which were control group, teprenone group, 30, 100 and 300 mg/kg
rebamipide groups. The first two parts evaluated the changes of GMBF and pH of gastric perfusate after using these reagents. The third part evaluated the gastric mucosal ulcer area induced by exposure to 0.15 mol/L HCl 40% ethanol. Results: In the 100 mg/kg and 300 mg/kg rebamipide groups, the mean increases of GMBF were (14.55±4.29)×10 -2 ml·min -1 ·g -1 and (21.14±6.19)×10 -2 ml·min -1 ·g -1 ; and the mean increases of gastric perfusate pH were 0.25±0.13 and 0.41±0.15; the mean ulcer area were (19.60±4.09) mm 2 and (5.00±2.75) mm 2. The statistic differences between the above data and those of control group were significant. Conclusion: Rebamipide can increase GMBF, accelerate gastric bicarbonate secretion and partially prevent gastric mucosa lesion by exposure to 0.15 mol/L HCl 40% ethanol.