Intravenous infusion of sodium fructose 1,6 diphosphate (FDP) 9 g (with FDP 7.54 g), oral administration of sodium fructose
1,6 -diphosphate 36 tablets (FDP 7.54 g) and Esafosfina Glutarlmmica 60 tablets (FDP calcium formulation; FDP 7.56 g) were given in 10 male health volunteers with randermized-cross and auto-pair method, respectively. Plasma FDP was detected by enzymatic method to observe
absolute bioavailability of oral ingestion of calcium or sodium fructose 1,6- diphosphate tablets. Cmax, Tmax and AUC were 367.5±17.0 mg·L-1, 12.4±2.0 min and 7119.9±1628.2 mg·h·L-1 after iv infusion, respectively. Following ingestion of sodium fructose 1,6 diphosphate and esafosfina glutalmmica tablets, Cmax, Tmax and AUC were 10.1±4.1 and 7.1±2.8 mg·L-1; 51.0 ±16.7 and 55.5±13.5 min; 387.5±191.9 and 298.1±160.2 mg·h·L-1, respectively. Absolute
Bioavailability was 5.8±3.2% in sodium tablet formulation and 4.3±2.5% in calcium tablet formulation. The data showed that absolute bioavailability of oral ingestion of either FDP sodium formulation or FDP calcium formulation was extremely low, only below 10%, compared with intravenous infusion FDP.