This article reported the results of the 61 patients with typhoid and paratyphoid fever treated with levofloxacin. Out of which, 40 cases were compared with cefixime (CFM) in randomized-control method. The clinical cure rate, effectiveness rate and the bacterial elimination rate were 97.5%, 100% and 100% respectively in the levofloxacin randomized group. In the cefixime group, the clinical cure rate, effectiveness rate and the bacterial elimination rate were all the same(90%). There were no significant difference in the two groups (P>0.05). The average days of the fever disappeared in the levofloxacin randomized group was 3.45±1.14 days. It was shorter than that (4.95±1.71 days) in the cefixime group (P<0.05). 61 patients were treated with levofloxacin at all. The clinical effective rate was 100% and all the initial pathogens were eradicated. The total adverse reactions rate was 3.27%. No cases of recurrence, relapse and bacterial carrier were observed during 3 months after treatment. In vitro. Levofloxacin showed strong antibacterial activity to salmonella thphi and paratyphi A.