The pharmacokinelics and relative
bioavailability of two kinds of
acyclovir tablet were determined following 400 mg oral
dose of
acyclovir given to 8 normal volunteers in an open randomized crossover study. A sensitive high performance liquid chromatographic method was used to determine the serum concenfration of acyclovir. The results indicated that the pharmacokinetics of this drug exhibited a linear 1-compartmant model. The Tmax values werc(0. 968±0. 224) h and (1. 157±0. 336) h, the Cmax values were (0. 555±0. 221) μg/ml and (0. 496±0. 149) μg/ml, the T1/2 ke values were (1. 426±0. 486) h. and (1. 630±0. 405) h, and the areas under the drug concentratio n-time curves (AUC) were (1. 844±0. 535) μg/(mg. h) and (1. 934±0. 483) μg/ (mg. h) for the tested and reference tablet, respectively. The relative
bioavailability of acyclovir of tested tablet vs reference tablet was (98. 18±12. 48) % and the CV % was (13. 11) %. The results in Tmax. Cmax, T1/2 Ke, and AvC high performance liguid chromatography showed that there is no evidence for statistical differences between the two kinds of tablet and they were bioequivalence.