The effects of carbon disulfide (CS_2) on gonadotropins and spermatogenesis in workers ex

The effect of carbon disulfide on gonadotropins and the spermatogenesis in workers exposed to CS_2 was studiedThe mean concentration of CS_2 in workplace was 32.60±5.14mg/m3,which was 3 fold higher than the maximal allowance concentration of national standardThe serum testosterone(T)、follicle stimulating hormone(FSH) and luteinizing hormone(LH) in 18 workers and some parameters of semen in 16 workers were measuredThe results showed:serum T level in CS2 group(1748±341mmol/L) was significantly lower than that of control (2307±551mmol/L),P<005In addition,LH(829±123IU/L)、FSH(752±281IU/L) in CS2 group were significantly higher than those in control,which were 559±086IU/L and 395±109IU/L respectively,P<001Sperm count in workers of CS2 group was decreased when compared with that of control,P<005The frequency of abnormal sperms in morphology was higher than that of control,but there was no statistical significanceThe results suggested that both the endocrine functions and gonad organ were disturbed in workers exposed to higher level of CS2,consequestly the spermatogenesis was decreased