Objective:To study the antiatherogenetic and anti lipid hyperoxidatic effects of Xuezhikang in
cholesterol fed rabbits.
Methods:The New Zealand white rabbits were randomized into three groups:control group,high lipid group and therapy group.The changes of serum total
cholesterol(TC),triglyceride(TG),high density lipoprotein cholesterol( HDL C ),low density lipoprotein cholesterol(LDL C),lipid peroxide(LPO),superoxide dismutase(SOD)concentrations and the histopathological changes of aorta and coronary arteries were detected. Results:Xuezhikang could
remarkably decrease the level of TC,TG,LDL C in serum of rabbits fed a high cholesterol diet( p <0 05),mildly increase the level of HDL C in serum( p >0 05).Xuezhikang could remarkably inhibit the formation of LPO in plasma( p <0 05),liver and kidney( p <0 05),and the decrease of SOD in the therapy group( p <0 05),the ratio of the area of atherogetic decreased,the layers of foamcells were remarkably decreased,the lesion of the aorta and coronary artery was remarkably depressed. Conclusion:Xuezhikang was remarkably effective to modulate the lipid metabolism and to inhibit the injury formation of and of lipid hyperoxidation.