Pharmacokinetic of inhaling fluorouracilum by ultrasonic atomizer and the concentration in lungs and

OBJECTIVE: To determine the concentrations of fluorouracilum in serum, lungs and tumour in patients was lung cancer after inhaling fluorouracilum by ultrasonic atomizer, and check the method against the conventional methods. METHODS: 10 patients with lung cancer served as targets of the experiment. A high performance liquid chromatography method with a 5 μm Kromasil C18 column 4.6 mm×200 mm and a mobile phase consisted of acetonitrilemthanol0.025 mol·L-1 K2HPO4 solution (10∶40∶50) was used. After fluorouracilum inhaled 250 mg: 10 ml, serum samples were collected at 2, 5, 10, 20, 30, 45, 60, 90, 120, 240 min and tissue samples obtained duing operation. The data obtained were fitted with PKBPN1 pharmacokinetic progarm on a computer. RESULTS: The results showed that the disposion of fluorouracilum was conformed to a twocompartment model with t1/2Ka=0.10 h, t1/2α=0.15 h, t1/2β=0.34 h, tmax=0.23 h and cmax=2.32 μg·ml-1. The concentration of tissue of lung and tumour was 0.37 μg·g-1 and 0.44 μg·g-1. CONCLUSIONS: The assimilate rate for fluorouracilum is fast and the harmful effects are less and light with the inhaling fluorouracilum by ultrasonic atomizer rather than old preparation.