Rosa roxburghii tratt Likangyin is a kind of heavy metalseliminating drinkables developed by us and Rosa roxburghii tratt juice is one of its main raw and processed materials.Wistar rats were prepared to be manganese intoxicated models by giving intraperitoneally MnCl 2·4H 2O(15 mg/kg) daily and ten were divided randomly according to blood manganese levels into 3 equal groups:manganese poisoning group;drinking Likangyin group and the group of giving intraperitoneally sodium paminosalicylate(PASNa)(120 mg/kg) daily.Another group of nonmanganese treated rats was also observed as negative control.The results demonstrated that the increases of body's manganese and copper contents and the decreases of body's zine contents were found in manganese intoxicated rats.Likangyin could increase the excretion of excrements manganese and decrease the contents of serum and brain manganese.The contents of serum and brain zine in manganese poisoning rats were raised by Likangyin.PASNa was effective in eliminating manganese,but it has no effect of replenishing trace elements.The experiment suggested that Likangyin was effective in eliminating manganese and in decreasing body's manganese burden and played a role in replenishing trace elements.