AIM:To study the property of
poloxamer 407,a reverse-thermal gelation,and the release of fluorofur from fluorofur/poloxamer
407 gel matrices. METHODS:The fluoro-fur/
poloxamer 407 formulations were made up in a pH(7. 40±0. 01) phosphate buffer,and the in vitro release studies were conducted at 37℃. RESULTS:The formulations of fluorofur/poloxamer 407 gel matrices existed as a mobile viscous liquid at reduced temperatures but formed a rigid semisolid gel network with an increase in temperature. The release of fluorofur from the gel matrices in vitro at 37℃ followed zero-order release kinetics. The cumulative percentages of fluorofur released at 37℃,8hr were (98.22±0.12)%, (86.20±0. 20)%, (68.25±0.14)%,(50.02±0.08)% for the 20%, 25%, 30% and 35 %(m/m) fluorofur/ poloxamer 407 formulations,respectively.CONCLUSION:Based on the rapid sol-to-gel transition, it appears that poloxamer 407,may potentially be useful for the formulation and sustained delivery of select drug Pharmaceuticals following extravascular administration.