The effect of Jiaweifoshuosan on
erythrocyte membrane fluidity and erythrocyte ultrastructure were studied with male and
pregnant rats of passive smoking. The red blood cell membrane fluidity was studied by marking the different domains of red cell membrane with fluorescence probes ANS and DPH. The results indicated that the fluidity of
erythrocyte membrane in model group were decreased significantly compared with the control group(P<0.01) and treated group(P<0.01), except the fluidity examined by marking the erythrocyte membrane with fluorescence probe DPH in pregnant rats. The defromed red blood cells under scanning and transmission electron microscopy were more in model group than in control group(P<0.001) and treated group(P<0.001). The data mentioned above were all improved conspicuously in treated group and there were no significant difference between treated and control group(P>0.05). The results suggest that the
Jiaweifoshousan has the effects of conserving the normal fluidity of erythrocyte membrane and normal ultrastructure of erythrocyte, thus improving the deformability of red blood cells and increasing the microcirculation perfusion.