Objectivc To study the anti - gastric ulcer effect of Weixianzhi and its mechanism. Method: The rats were divided into four
groups: control group (distilled water 2.0ml/time), famotidine (0. 018% 2. 0ml/time ), high dose of Weixianzhi (100% 2. 0ml/time ) and low dose of Weixianzhi (50% 2. 0ml/ time). Each of them lvas administered orally two times per day and 15 days in succession. After the last time, the tals were had 48 hours, gastric ulcer model of rats was made by using the ligation of pylorus. Then 19 hoare later, the rats' heads were cut out and dissection performed. The
gastric juice was collected and analyzed. Results: In drug given groups the ulcer index, quantity of gastric juice, free acidity ,
total acidity and acitvity of pepsin of the rats were all lower than those of control group. Conclusion:The results suggest that Weixianzhi has a significant effect on gastric ulcer induced by the ligation of pylorus. It can inhibit secretion of gastric juice and reduces free acidity and total acidity of the stomach and the activity of pepsin. This indicates that Weixianzhi may produce anti gastric ulcer effects by inhibiting secretions of gastric juice.