The SD rats were randomly divided into normal group, CCl 4、TMP and colchicine groups. The experiment results showed that
the activities of serum ALT, the contents of malondialdehyde (MDA),PCⅢ、HA in serum and MDA in hepatic tissue of TMP group were
significantly lower. The activities of SOD in hepatic tissue of TMP group were significantly higher, the degrees of proliferation of collagen fibers, the numbers of desmin positive cells in hepatic tissue of TMP group were significantly lower than those in CCl 4 group, wherease there were no significant differences in the levels of serum PCⅢ and HA, the contents of HA, the numbers of desmin positive cells and the degrees of collagen fiber proliferation in hepatic tissue between TMP group and colchicine group. This experiment suggests that the anti hepatofibrotic efficacies of TMP and colchicine are similar but their effect mechanisms are different. Colchicine has no the protective effect, which TMP has, no hepatocytes against
lipid peroxidation.