French scientists had discovered where the
virus of the AIDS hides its "reservoir" in the body of submitted patients the
continuous treatment against the illness. The study he will be able to bring answers for the question that has much uneasy time all the researchers of the world: after years of intensive treatment against the HIV, the patients they lowered the viral load to such point that an examination would not accuse the presence with the illness in the body; however, an interrupted time the use of coquetel anticAids, the
virus comes back if to reproduce quickly and if to waste one more time in the body.
The studious famous Frenchmen of the Institute Pasteur and National Institut of the Health and Medical Research (Inserm), in Paris, affirm that he is in the lymphatic ganglia of the intestinal region that the virus if occults. Most important he was to prove the place of the hiding place in the infectados patients and tratad it more than has ten years, whose viral load arrives at a indetectável point. "We show that this '' deep reservoir '' if points out essentially in the mesentéricos ganglia, that drain the region intestinal, and not in the Peyer plates, situated in the interior of the col, also in the treat individuals that haven''t particles capsize detectable in the blood or in the peripheral ganglia after 10 years of infection ", the coordinator of the study said, Jérôme Estaquier, to the periodical Le Figaro. The researchers had also perceived that the linfócitos, responsible for the defense of the human body, they do not play its role in the place well because they present a "supervened defect of" in that part of the body. These linfócitos habitually would have to be capable to control the virus, destroying the infectadas
cells, however they are dying before the one that would have. This harm-formation could be the cause of the imperfection in the definitive combat of the virus. From now, the focus of the research - whose resulted they had been published in the edition of July of the scientific magazine Cell Death and Differentiation - will be to fortify linfócitos, called T CD8, and to make possible that they "they win" the HIV at the moment where the viral load if finds only hidden in the intestinals lymphatic ganglia. An initial step in this direction already was given: the scientists had identified the molecule that can be the responsible one for the anomaly of the linfócitos T CD8. One is about the TGF-beta, a imunossupressiva citocina (protein that low the immunity). This citocina also is implied in the defense of the body against the cancerous cells, as previous studies. "the strategies will be to inhibit the imunossupressivas functions of the TGF-beta or to restore the supervened one of cells T CD8, what in it will better make possible them to control the virus ", affirmed the Estaquier to the French periodical.
Source:
http://noticias.terra.com.br/ciencia/interna/0, OI1824850-EI8148, 00.html