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Shvoong Home>Medicine & Health>Broccoli and cauliflower reduce aggressive prostate cancer risk. Review

Broccoli and cauliflower reduce aggressive prostate cancer risk.

Article Review   by:Veswan     Original Author: Dr. Niphon Nimboonchaj.
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Write your abstract here.Broccoli and cauliflower reduce aggressive prostate cancer risk.



A study reported in the August 1, 2007 issue of the Journal of the National Cancer Institute concluded
that men who consume more cruciferous vegetables, particularly broccoli
and cauliflower, have a lower risk of aggressive prostate cancer. The
cruciferous family of vegetables, which also includes cabbage, kale,
and Brussels sprouts, has been associated in previous research with
protection from colon, breast, prostate, thyroid, cervical, and other
cancers, as well as with slower disease progression.

For
the current study, Victoria Kirsh, PhD, of Cancer Care Ontario in
Toronto and colleagues utilized data from 29,361 men participating in
the Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial. Over
the 4.2 year average follow-up period, 1,338 men were diagnosed with
prostate cancer, including 520 with aggressive disease. Dietary
questionnaires completed by the participants were analyzed for the
association of fruits and vegetables with prostate cancer risk.
While
total fruit and vegetable intake was not found to be related to
prostate cancer risk, higher intake of dark green as well as
cruciferous vegetables was found to be associated with a lower risk of
the disease, particularly that which was aggressive and had spread
beyond the prostate. Broccoli and cauliflower had especially strong
protective associations against aggressive and extraprostatic disease.
Men whose intake of broccoli was greatest, at more than one serving per
week, had a 45 percent lower risk of extraprostatic disease cancer than
men whose intake was least, at less than once per month. Cauliflower
was associated with an even greater benefit, with a 52 percent
reduction in risk experienced by men who consumed the vegetable more
than once per week. The gluocinsolate-derived compounds contained in
cruciferous vegetables modify cancer risk by protecting cells from DNA
damage, inducing apoptosis, influencing genetic expression, and
inhibiting! prostate cancer cell proliferation.
“Aggressive
prostate cancer is biologically virulent and associated with poor
prognosis. Therefore, if the association that we observed is ultimately
found to be causal, a possible means to reduce the burden of this
disease may be primary prevention through increased consumption of
broccoli, cauliflower, and possibly spinach,” the authors conclude.
Source: Life Extension
Published: November 08, 2007   
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