Biomedical science has made major advances in understanding how cells grow into functioning tissue and the signalling mechanisms
used to achieve this are slowly being dissected. Tissue
engineering is the application of that knowledge to the building or repairing of organs, including skin, the largest organ in the body.
Current treatment strategies in intensive care medicine for patients with burns of more than 80% of the total body surface area (TBSA) permits survival but major burns result in extensive skin defects. Thus, burn victims often suffer from scar contractures, altered thermoregulation, and unsatisfactory cosmetic results.
The recent ability to isolate stem cells and study their specific capacity of self-renewal with the
formation of different cell types has opened up exciting vistas to help the repair of damaged tissue and even the formation of new tissue. This approach should allow us to create a tissue-engineered substitute, which more closely resembles the normal regional microanatomy and physiology of the skin, allowing better integration to the host with minimal or no scarring…
Skin is the largest organ in human system and the first tissue-engineered organ to have been successfully developed in the laboratory in the year 2004,which plays a vital role as a barrier against environment and pathogens. Skin regeneration is important in tissue engineering especially in cases of chronic wounds. With the tissue engineering technology, these skins equivalent have been use clinically to repair burns and wounds.Cutaneous wound-healing disorders are a major health problem that requires the development of innovative treatment.