The cientist Bruce Banner searchs desperately an antidot to the gamma radiations that created Hulk. He lives in the shadows,
always in love with the beautiful Betty Ross (Liv Tyler) and goes across the planet searching for a cure.
Hulk''s destructor strenght attracts General Thunderbolt Ross (William Hurt) and his right-hand man Blonsky (Tim Roth) who dreams to use him with military purposes. They try to develop a serum to create strong soldiers.
Back to USA, Bruce Banner discovers a new enemy. After proving the experimental serum, Blonsky became the Abomination, a monster which strenght is upper to Hulk''s. He became the center of NYC.
To save New York from the total destruction, Bruce Banner will bring back the monster that lives inside him...