Objective:
Epidural pipe in the
epidural space in research in study is outside the epidural space of the dog inside variation,
over short, sell at a discount flection, the
epidural space glues to connect seriously, and epidural pipe is outside lucid and epidural space in amount to 3～4 cm. Above all kinds circumstances next,
morphine is outside the epidural space of the dog is in the proliferation, enter the blood circulation with permeate speed and quantities that subarachnoid space. To analysis research morphine is epidural space function process with painful result in town. Method: The surgical operation cuts open the spinal column of the dog, finding out theepidural space , experimenting the set put into the epidural pipe respectively 1cm in the epidural space,epidural pipe in the epidural space in sell at a discount, flection 1.5cm for 5 examples . Epidural space in matched control puts into the hard and outside pipe 3～4cm for 20 examples. Two sets all use the morphine 3 mgs infuses into with the epidural space in amount of in a the leader in brine in physiology in 0.9%.Then two sets are all a epidural pipe to link the painful pump in town, pumping the inside have the morphine 7 mgs adds 0.9% physiology brine 48 mls,24 hours empress take out takes two group dog vein blood with brain ridge liquid, examination blood with brain ridge liquid inside the morphine contains the deal. Result: The experiment set contains with matched control dog vein blood morphine the deal has no to show the difference .( P>0.05). The dog brain ridge liquid inside morphine contains the 2 sets : deal to near to( P>0.05) very much, painful result in town two groups have no painful efficient amount to 93% above, have no to show the difference .( P>0.05). Two group dog usage the toxicity that morphine causes respond the side effect to also have no to show the difference .( P>0.05). Conclusion: Place the tube in epidural space normal with over short, the epidural space is lucid with glue to connect serious, spread, enter the blood circulation in the epidural space of the dog to the morphine similar to permeate into subarachnoid space speed with density influence smallerly, painful result in town with strength and efficients is. So can calculate the morphine in ridge nerve root, spinal cord, functional morphine receptor the quantity similar to the deal that painful material in town release the enkephalin(ENK) etc. is or connect near.