AIM: To investigate the therapeutic effects of tinidazole membrane(TM) on
experimental periodontitis and its irritation on
oral mucosa in rats. METHODS: SD rats were ligated with silk floss on the first molar of right upper jaw,injected (im) with hydrocortidelt and fed with special food to induce
experimental periodontitis. Model animals were treated with TM by pasted on the lesion region for 7 days in succession(once a day), then the therapeutic effects were observed. The irritation of TM on the oral mucosa in rats was observed after TM were administrated 7 days. RESULTS: TM 0.075 , 0.175 and 0.375 mg per rat had significantly therapeutic effect on the soft tissues inflammation of experimental periodontitis, and their effects were as same as or superior to tinidazole 100 mg·kg -1 (ig). After TM 1.5 mg·cm -2 ( 0.5 cm × 0.5 cm ) were treated for 7 days in succession through pasted on the inside cheek,and the oral mucosa had no significant change. CONCLUSION: TM has significantly therapeutic effect on experimental periodontitis and no significant
oral mucosa irritation in rats.