AIM: To examine the function of the four
constituent medicines of Si Ni San(Composition of Radix Bupleuri,Radix Paeoniae alba, Fructus Aurantii immaturus and Radix Glycyrrhizae) and each single drug on alleviating experimental
liver injury METHOD:
Hepatocyte damage
induced by CCl 4 and PCl DTH,Con A induce lymphocyte proliferation,LPS induced NO
production in macrophage and gelatin zymography assay were used RESULT: The results show that the activities of Si Ni San were stronger than those of each constituent Among the four constituent medicines,Radix Bupleuri mainly affected the main process of liver injury through protecting hepatocyte membrane and enhancing NO,a protective factor,production in macrophages;Radix Paeoniae alba mainly affected immune cells through inhibiting the activation,migration and infiltration of lymphocytes,and inducing the dysfunction of liver infiltrating cells; Radix Glycyrrhizae had both hepatoprotective and immunomodulatory activities contributing to SNS alleviating liver injury CONCLUSION: Each constituent of Si Ni San affects the different target of liver injury and their comprehensive
effect resulted in the stronger effect of the prescription
More summaries about the Effect of Si-Ni-San and Its Individual Component Drugs on Experimental Liver Injury