objective To investigate the effects of
losartan,a specific blocker of angiotensinⅡ(AngⅡ)receptor(AT1),on vascular remodeling
and p38MAPK expression in two-kidney,one-clip hypertensive rat.Methods The sys-temic blood pressure(SBP)was measured by tail-cuff method and carotid cannulation.The morphologic change of aor-tas was analyzed after HE staining.Western blot was per formed to detect p38MAPK expression.Result The SBP in
hypertension group was significantly higher than that of control group(158±7mm Hg vs104±11mm Hg,P<0.05);treatment with losartan normalized SBP(132±9mm Hg).The ratio of lumen to media of mesenteric resistance arteries was decreased obviously in hypertension group;treatment with losartan improved
vascular remodeling.The expression of p38MAPK increased in hypertension group,treatment with losartan could decrease the expression.Conclusion Losartan could prevent development of hypertension by regulating vascular remodeling in2KIC hypertensive rats,the mechanism is maybe to inhibit AngⅡsignal pathway or regulate expression of p38MAPK.