Objective Effects of
Fufang danshen Granule on expression of
adhesion molecules CD11a,CD61and ICAM-1were studied by endotoxin
in rat.To discuss the mechanismthat Fufand danshen prevented cell adhesion and improved microcirculation.Methods Rats in group1and group2were adminitsted with o.5g and0.3g of
Fufang danshen solution respectively two times/day,feeding for10days.In normal group and Control no medicine was given.Inject Endotoxin1mg/kg into tail vein for each group except normal group.CD11a and CD61,ICAM-1wre measured after2and4hours respectively.Results The CD61expression(142.3±23.2)in Fufang Danshen group1increased more obviously than that in control group(126.2±19.6)2h after injecting endotoxin.Expression of CD61in group1and2decreased more obviously than that in control group4h after injection of enˉdotoxin.CD61expression in group1and2is close to that in normal group.There is no significant difference of exˉpression of CD11a and ICAM-1in Fufang Danshen compared with that in control group.Conclusions Fufang Danshen group can relieve platelet to adhere and gather,reduce blood viscosity by decreaseing platelet adhesion expression of CD61.It plays a role to improve microcirculation.