Objective:To investigate effects of
Yangxin Tongmai Tabellae (YTT) on apoptosis and singnal transmission of actin in aort
of rat modelswithinsulin resistance syndrome(IRS).Methods:Using the method of high fat-high glucose-high salt feeding to build the rat models with IRS,the rat models were randomly divided into 3 groups,YTT group,metformin (met) group and pathology group,as healthy controls group,which they were treated 30-days with YTT,met and pure water,respectively.The percentage of apoptosis and expression of actin in the aorta of rat models were measured and analysed compared with healthy controls group.Results:The percentage of apoptosis and average D λnmvalue of actin increased in turns from healthy controls group to YTT group,to Met group,to pathology group(P<0.01).Besides,the percentage of apoptosis and average D λnm value of actin in YTT group were significantly dropper than Met group (P<0.01orP<0.05).Conclusions:Effect of YTT on apoptosis and expression of actin was evidently superiorto Met.