Objective To observe the protection of Radix Isatidis -
liposome on
macrophage membrane lipid fluidity in endotoxemia mice.Methods Mice were divided into 4 groups:Radix Isatidis
chlorform extract
pretreated group,liposome pretreated group,
Radix Isatidis-liposome pretreated group and endotoxemic group as control.Each group was given intraperitoneally 5ml/kg drug as above order,and then 6mg/kg LPS was given intraperitoneally after pretreated 18h.Mice were dispatched after 6h,the change of macrophage
Membrane fluidity was observed.Results Protection of Radix Isatidis chlorform extract had not reached a significant level in statistics(P>0.05),liposome had a significant protection(P<0.05),but between each other no differentiation in statistics(P>0.05);Radix Isatidis-liposome had more better protection(P<0.01) than Radix Isatidis chlorform extract (P<0.05)or liposome(P=0.05)alone did.Conclusion Radix Isatidis-liposome have more better protective effect on macrophage membrane lipid fluidity than Radix Isatidis chlorform extract or liposome alone dose.
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