Objective: To study the prevention and treatment effects of
Radix Bupleuri (柴胡) and
Radix Scutellariae (黄芩) in compatibility
ratio of different dosage on acute ethanol intoxication and the related mechanism. Methods: In the experiments, mouse models were duplicated by the white spirit through consecutive gastric infusion for ten days. Radix Bupleuri, Radix Scutellariae and Xiao Chaihu Decoction (小柴胡汤) were used as positive control medicines, respectively. The prevention and treatment effects of Radix Bupleuri and Radix Scutellariae in compatibility were studied by investigating common states, comparing the changes in the indexes of liver, measuring the vitality of ALT and AST in blood serum and the liver contents of MDA. Results: Radix Bupleuri and Radix Scutellariae in compatibility by the ratio of one to two had the most obvious effect in the experiment. Conclusions: The results of alcoholic injure in mice demonstrated consistently Radix Bupleuri and Radix Scutellariae in compatibility by the ratio of one to two had the best function.