Objective:To observer the effects of allicin on muscle damage at different phases after
eccentric exercise and change of
blood IL-6,CK and CK-MM,Ca~ 2+ .Method:80 SD rats were randomly divided into the simple
exercise group (A),and exercise plus allicin group (B).All rats of group B were injected parenteral solution of allicin (20mg/kg) for two weeks.Treadmill (19-21m/min,-16°and 90min) test was made for rats.After exercise,soleus muscle was obtained and blood sample were elicited from femoral artery.The fibrous structure and changes of the blood IL-6,CK and CK-MM,Ca~ 2+ were observed.Result:The ultrastructure of skeletal muscle of two groups was changed and damaged.The changes of group B was slightly smaller than that of group A.Plasma IL-6 of group A increased significantly after exercise.Serum CK and CK-MM increased obviously after exercise.Instant and 24 hours of group B were lower than those of group A.Conclusion:Allicin redounded to alleviate the ultastructure damage induced by
eccentric exercise.It can restrain the enhancement of plasm IL-6.It indicated that allicin can protect the permeability and integrality of cell membrane.