OBJECTIVE To study the pharmaeokineties and
relative bioavailability oi
ampicillin and
probenecid oral suspension in Chinese healthy volunteers. METHODS According to crossover design, each volunteer was given a single oral dose of test
preparation and reference preparation. The serum concentrations of ampicillin and probenecid were determined by high performance liquid chromatograpby. Phanna-cokinetic paramters were calculated. The analysis oi variance and two one-side t test were used to evaluate the variance between 2 groups. RESULTS The AUC0→8, AUC0→∞ , Cmax, tmax and t1/2 of ampieillin in lest oral suspension arid the reference capsules were (27.6 ± 7.9) and (31.1±7.1),μg·h·mL-1, (29.4±8.1) and (33.2±7.3) μg·h·mL-1 , (8.2±2.8) and (8.1 ?.2)μg·mL-1 , (2.0 ± 0.6) and (2.1
± 0.5)h, (1.62 ± 0.48) and (1.57 ± 0.43)h, respectively. The AUC0→24 , AUC0→∞, Cmax, tmax and t1/2 of probenecid in test oral suspension and the reference capsules were (174.3 ± 35.8) and (178.2 ± 40.7)μ·h·mL-1, (180.5 ± 37.9) and (186.6 ± 43.1)μg·h·mL-1 , (21.8
±4.5) and (24.3±5.0)μg·ML-1, (2.4±0.8) and (2.3 ±0.6)h, (4.73±0.79) and(4.98±1.03)h, respectively. There were no significant differences in the pharmacokinetic parameters between test preparation and reference preparation. Compared with reference preparation, the relative
Bioavailability of ampieillin and probenecid of test preparation were (89.0±17.6)% and (99.4±15.4)% respectively. CONCLUSION The result of statistical analysis shows that the 2 preparations are bioequivalent.
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